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03 Aug 2021

How Real NAD+ Gave Rise to NADIA Skincare

NADIA is a new line of skincare from Avior Nutritionals®, the makers of Real NAD+®. The name NADIA is an acronym for Nicotinamide Adenine Dinucleotide In Action. A coenzyme found in all living cells, Nicotinamide Adenine Dinucleotide, better known as NAD+, plays an important role in DNA repair, mitochondrial functioning, telomere integrity, and in the systems responsible for removing waste from the cell [2,4]. Studies show that supplementing the body’s level of NAD+ can provide a wide range of benefits [1,5].

For years, physicians across the country and from varying specialties have relied on Avior Nutritionals® and its affiliate, Archway Apothecary, to provide optimally sourced NAD+ in intravenous, oral, and topical forms. Real NAD+® is an EZ melt supplement developed by Avior Nutritionals® and available to physicians. Over the years, many of these physicians reported that significant skin benefits often accompany NAD+ supplementation. They began requesting a topical form. As a compounding pharmacy, Archway Apothecary was able to oblige with an NAD+ face cream that was individually blended, but available only by prescription. In spite of its simple formulation, pasty consistency, and acrid scent, demand continually increased for this original NAD+ cream. In 2018, Avior Nutritionals® began development on a full line of luxury skincare that not only featured twice the amount of pure NAD+ as its predecessor, but also included all of the moisturizing agents, peptides, antioxidants, and pleasing aromatic qualities that consumers have come to expect from high end skincare. It took two years, a team of chemists, a dozen prototypes, and a grueling physician review process, but in November of 2020, NADIA Skincare™ officially launched to the healthcare community.

Why NAD+?

NAD+ is in every cell in our body and is a cofactor in hundreds of enzymatic reactions. It regulates cellular metabolism, mitochondrial efficiency, and DNA repair [9]. It is a catalyst for the communication and waste removal processes within the cell. If skin cells cannot communicate, if they cannot rid themselves of waste, then all of the active ingredients and protective antioxidants that we apply to our skin cannot do what they are intended to do.

Our skin is our largest organ, has a higher rate of cellular turnover than other parts of our anatomy, and is exposed to constant environmental assault [4]. Cells are bombarded with free radicals and suffer oxidative stress from mechanical and chemical insults such as solar radiation, pollution, and poor nutrition [4]. It is the accumulation - day after day, year after year - of these insults that leads to premature signs of aging [4]. Skin cells have a higher need for NAD+ than many other types of cells [7].

Our NAD+ levels decline as we age. Recent studies indicate that NAD+ decline may drive many components of aging [4]. Supplementing NAD+ topically can increase mitochondrial energy production, support sirtuins, also known as “longevity genes,” and effectively reduce signs of aging [1].

For decades, medical science has been working to understand, assist, and emulate the body’s mechanism for DNA repair and cellular support. In this quest, one very important molecule stood out, NAD+. Supplementation with NAD+ is a scientific breakthrough in anti-aging, which is why it is at the core of NADIA Skincare™, and why it is hailed for its ability to repair damage at a cellular level and promote a lifetime of healthy skin.

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

[1] Chen, Andrew C, and Diona L Damian. “Nicotinamide and the skin.” The Australasian journal of dermatology vol. 55,3 (2014): 169-75. doi:10.1111/ajd.12163

[2] Massudi, Hassina et al. “Age-associated changes in oxidative stress and NAD+ metabolism in human tissue.” PloS one vol. 7,7 (2012): e42357. doi:10.1371/journal.pone.0042357

[3] Miyamoto K, Kudoh H. “Quantification and visualization of cellular NAD(P)H in young and aged female facial skin with in vivo two-photon tomography.” Br J Dermatol. 2013 Jul;169 Suppl 2:25-31. doi: 10.1111/bjd.12370. PMID: 23786617.

[4] Oblong JE. “The evolving role of the NAD+/nicotinamide metabolome in skin homeostasis, cellular bioenergetics, and aging.” DNA Repair (Amst). 2014 Nov;23:59-63. doi: 10.1016/j.dnarep.2014.04.005. Epub 2014 Apr 30. PMID: 24794404.

[5] Radenkovic, Dina et al. “Clinical Evidence for Targeting NAD Therapeutically.” Pharmaceuticals (Basel, Switzerland) vol. 13,9 247. 15 Sep. 2020, doi:10.3390/ph13090247

[6] Singh, B., Schoeb, T.R., Bajpai, P. et al. “Reversing wrinkled skin and hair loss in mice by restoring mitochondrial function.” Cell Death Dis 9, 735 (2018). https://doi.org/10.1038/s41419-018-0765-9

[7] Surjana, Devita et al. “Role of nicotinamide in DNA damage, mutagenesis, and DNA repair.” Journal of nucleic acids vol. 2010 157591. 25 Jul. 2010, doi:10.4061/2010/157591.

[8] Thompson, Benjamin C et al. “Nicotinamide enhances repair of arsenic and ultraviolet radiation-induced DNA damage in HaCaT keratinocytes and ex vivo human skin.” PloS one vol. 10,2 e0117491. 6 Feb. 2015, doi:10.1371/journal.pone.0117491

[9] Wozniacka, A et al. “In search for new antipsoriatic agents: NAD topical composition.” Skin pharmacology and physiology vol. 20,1 (2007): 37-42. doi:10.1159/000096170